T. Ruppert

Structural and Immunological Similarities Between the Metacyclic and Bloodstream Form Variant Surface Glycoproteins of the African Trypanosome

This study shows metacyclic and bloodstream form VSGs of African trypanosomes are structurally and immunologically similar.

Replicative aging impedes stress-induced assembly of a key human protein disaggregase

This study identifies a stress-induced trimeric protein disaggregase in human cells that collapses during replicative aging, contributing to pathophysiological consequences.

Immunodominant surface epitopes power immune evasion in the African trypanosome

The paper shows that immune responses to African trypanosome VSGs are focused on immunodominant epitopes, enabling immune evasion through epitope variation.

Targeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation

This study develops a targeted proteomics assay to quantify low-abundance glycosyltransferases in CDG patients, revealing specific protein level changes in ALG1 and ALG2 mutants.

Glycosyltransferase POMGNT1 deficiency affects N-cadherin-mediated cell-cell adhesion

This study shows that POMGNT1 deficiency increases N-cadherin levels and alters its N-glycan structures, enhancing cell-cell adhesion and activating EMT-like signaling pathways.

Mechanisms of up-regulation of Ubiquitin-Proteasome activity in the absence of NatA dependent N-terminal acetylation

The paper investigates how UPS activity increases in NatA mutants and identifies mechanisms involving Rpn4 regulation, E3 ligase abundance, and Tom1's role as an E4 ligase.