S. Arumugam

Single-molecule Mapping of Amyloid-β Oligomer Insertion intoLipid Bilayers

This study uses QSLIP to map amyloid-beta oligomer membrane insertion, finding toxicity correlates with amino-terminal penetration depth.

Curtailed CaSR expression in peripheral blood mononuclear cells is associated with hypertension

The paper investigates reduced CaSR expression in hypertensive models and links it to impaired NO production and altered Ca2+ dynamics.

Paneth cells disruption and intestinal dysbiosis contribute to the development of Hirschsprung-associated enterocolitis in a benzalkonium chloride-induced Hirschsprungs disease rat model

This study shows that Paneth cell disruption and intestinal dysbiosis contribute to Hirschsprung-associated enterocolitis in a BAC-induced HSCR rat model.

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses

This study identifies broad-spectrum antiviral agents effective against multiple RNA virus families, including arboviruses and respiratory pathogens.

Replicative aging impedes stress-induced assembly of a key human protein disaggregase

This study identifies a stress-induced trimeric protein disaggregase in human cells that collapses during replicative aging, contributing to pathophysiological consequences.

Deterministic Early Endosomal Maturations Emerge From a Stochastic Trigger-and-Convert Mechanism

The paper tracks endosomal maturation events using advanced imaging and simulations, revealing that maturation is driven by heterotypic EEA1-mediated interactions rather than autonomous stochastic processes.

Possible Interference in Protein - Protein interaction as a new approach in microinhibition of respiratory pathogens on nasal- oral epithelium: An early on-screen study with reference toSARS-Cov-2-ACE2 binding interference

The paper investigates the interference of Lysine on protein-protein interactions and phospholipid bilayer behavior as a potential micro-inhibition strategy for respiratory pathogens on nasal/oral epithelium.

MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

E-cadherin regulates the stability and transcriptional activity of β-catenin in embryonic stem cells

This study shows E-cadherin stabilizes and activates β-catenin in mouse ESCs, influencing cell-state-dependent gene expression and differentiation.

Rapid Whole Cell Imaging Reveals A Calcium-APPL1-Dynein Nexus That Regulates Cohort Trafficking of Stimulated EGF Receptor

The paper uses whole-cell imaging to reveal a calcium-APPL1-dynein mechanism that directs EGFR trafficking to the peri-nuclear region.

Microbiome and Metabolome driven differentiation of TGF-beta producing Tregs leads to Senescence and HIV latency

The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.

Combination of photoactivation with lattice light-sheet imaging reveals untemplated, lamellar ruffle generation by PA-Rac1

The paper uses optogenetic PA-Rac1 and lattice light-sheet imaging to show Rac1 drives untemplated lamellar ruffle formation without a template.

Folding landscape of a parallel G-quadruplex

The paper investigates the folding pathway of a G-quadruplex using spectroscopic and computational methods, revealing multiple intermediates and a slow unfolding process.

The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation

This paper shows that the yeast Set1 complex is dimeric, leading to symmetric H3K4me3, and that Jhd2 demethylase removes asymmetric H3K4me3, working together to establish epigenetic symmetry.