Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility
P. J. Spreacker, N. E. Thomas, W. F. Beeninga, M. Brousseau, C. J. Porter, K. M. Hibbs, K. A. Henzler-Wildman
The paper shows that the E. coli SMR transporter EmrE can confer susceptibility to small-molecule substrates like harmane by triggering proton uniport, leading to antibiotic synergy.
bioRxiv · Dec 4, 2021 · PreprintBiochemistry