Author

C. J. Porter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

K. A. Henzler-Wildman· 3 shared P. J. Spreacker· 3 shared W. F. Beeninga· 3 shared A. Giganti· 1 shared A. Wegrzynowicz· 1 shared B. L. Young· 1 shared B. Liu· 1 shared C. Bourrier· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

K. A. Henzler-Wildman

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Author profile →

4 papers

Recent·Most cited

Functional promiscuity of small multidrug resistance transporters from Staphylococcus aureus, Pseudomonas aeruginosa, and Francisella tularensis

P. J. Spreacker, C. J. Porter, A. Wegrzynowicz, W. F. Beeninga, S. P. Demas, E. N. Powers, K. A. Henzler-Wildman

The paper tests whether functional promiscuity of SMR transporters extends to homologs from three pathogens, finding they can confer resistance or susceptibility to different substrates in E. coli.

bioRxiv · Nov 22, 2022 · PreprintMicrobiology

Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility

P. J. Spreacker, N. E. Thomas, W. F. Beeninga, M. Brousseau, C. J. Porter, K. M. Hibbs, K. A. Henzler-Wildman

The paper shows that the E. coli SMR transporter EmrE can confer susceptibility to small-molecule substrates like harmane by triggering proton uniport, leading to antibiotic synergy.

bioRxiv · Dec 4, 2021 · PreprintBiochemistry

Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor

B. Liu, I. R. Chandrashekaran, O. Ilyichova, D. Valour, F. Melchiore, C. Bourrier, A. Giganti, J.-P. Stephan, C. Dacquet, P. Genissel, W. Gosgnach, R. J. Weaver, C. J. Porter, M. J. Scanlon, M. L. Halls

This study shows that certain fatty acid binding proteins (FABPs) modulate glucocorticoid receptor (GR) transcriptional activity in a ligand-dependent manner, potentially enabling more targeted GR-based therapies.

bioRxiv · Jul 2, 2021 · PreprintPharmacology & Toxicology

Functional phenotyping of small multidrug resistance proteins from Staphylococcus aureus and Francisella tularensis reveals functional homology to EmrE

P. J. Spreacker, W. F. Beeninga, B. L. Young, C. J. Porter, K. A. Henzler-Wildman

The paper functionally characterizes EmrE-like SMR transporters from Staphylococcus aureus and Francisella tularensis, showing they are functionally similar to EmrE and distinct from GdX-like SMRs.

bioRxiv · Jan 6, 2021 · PreprintMicrobiology