Author

K. M. Humphries

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Batushansky· 2 shared C. A. Eyster· 2 shared S. Matsuzaki· 2 shared A. Jopkiewicz· 1 shared A. Pranay· 1 shared B. L. Loveland· 1 shared D. Makosa· 1 shared H. Van Remmen· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPhysiology

A. Batushansky

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart

K. M. Harold, S. Matsuzaki, A. Pranay, B. L. Loveland, A. Batushansky, M. F. Mendez Garcia, C. A. Eyster, S. Stavrakis, Y. A. Chiao, M. Kinter, K. M. Humphries

This study shows that loss of cardiac PFKFB2 leads to metabolic, functional, and electrophysiological changes in the heart, including impaired systolic function and altered electrophysiology.

bioRxiv · Nov 22, 2023Physiology

Sirt5 deficiency causes post-translational protein malonylation and dysregulated cellular metabolism in chondrocytes under obesity conditions

S. Zhu, A. Batushansky, A. Jopkiewicz, D. Makosa, K. M. Humphries, H. Van Remmen, T. M. Griffin

This study shows that Sirt5 deficiency increases protein malonylation and disrupts metabolism in chondrocytes under obesity conditions, linking it to osteoarthritis progression.

bioRxiv · Nov 30, 2020Cell Biology

Diabetes induced decreases in PKA signaling in cardiomyocytes: the role of insulin

C. A. Eyster, S. Matsuzaki, J. R. Giorgione, K. M. Humphries

This study shows that diabetes impairs PKA signaling in cardiomyocytes, with insulin deficiency contributing to reduced phosphorylation of PFK-2, a key metabolic regulator.

bioRxiv · Apr 2, 2020Cell Biology