Author

K. M. Pearce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Organism:rat· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

B. Rosati· 1 shared J. Srinivasan· 1 shared L. Jackson· 1 shared M. Bell· 1 shared O. Garwain· 1 shared P. Rangamani· 1 shared Q. Wen· 1 shared S. Carley· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

B. Rosati

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2 papers

Recent·Most cited

Simulation of the Gαq /Phospholipase Cβ1 Signaling Pathway Returns Differentiated PC12 Cells to a Stem-like State

O. Garwain, K. M. Pearce, L. Jackson, S. Carley, B. Rosati, S. S. Scarlata

The paper shows that reducing PLCβ1 or activating Gq to move PLCβ1 to the plasma membrane reverts differentiated PC12 cells to a stem-like state, characterized by morphology changes, proliferation, and expression of stem cell factors.

bioRxiv · Jan 6, 2020 · PreprintBiochemistry

Gq-mediated calcium dynamics and membrane tension modulate neurite plasticity

K. M. Pearce, M. Bell, W. Linthicum, Q. Wen, J. Srinivasan, P. Rangamani, S. Scarlata

This study shows that Gq-mediated calcium dynamics and membrane tension regulate neurite retraction and synaptic disruption in PC12 cells and C. elegans.

bioRxiv · Oct 9, 2019 · PreprintBiophysics