Author

K. M. Semesta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

N. G. Tsvetanova· 2 shared A. Garces· 1 shared M. Kampmann· 1 shared M. von Zastrow· 1 shared R. Tian· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersCell Biology

N. G. Tsvetanova

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2 papers

Recent·Most cited

The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction

K. M. Semesta, A. Garces, N. G. Tsvetanova

This study identifies RBM12 as a repressor of the GPCR/cAMP/PKA signaling pathway, showing that its loss leads to hyperactive signaling and altered transcriptional responses in neurons.

bioRxiv · Jan 12, 2023 · PreprintCell Biology

A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling

K. M. Semesta, R. Tian, M. Kampmann, M. von Zastrow, N. G. Tsvetanova

The paper develops a CRISPR interference screen to identify regulators of GPCR/cAMP signaling, identifying 45 strong and 50 weaker regulators, and validates seven novel mediators.

bioRxiv · Sep 2, 2020Cell Biology