Author

K. Meador

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein design· 2 Assay:protein structure· 2 Assay:cryo-EM· 1 Approach:machine learning (classical)· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

R. Castells-Graells· 3 shared T. O. Yeates· 3 shared M. A. Arbing· 2 shared M. R. Sawaya· 2 shared A. D. Laganowsky· 1 shared C. Phillips· 1 shared C. Senarathne· 1 shared D. Cascio· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

R. Castells-Graells

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3 papers

Recent·Most cited

Design of a symmetry-broken tetrahedral protein cage by a method of internal steric occlusion

N. Gladkov, E. A. Scott, K. Meador, E. J. Lee, A. D. Laganowsky, T. O. Yeates, R. Castells-Graells

The paper designs a symmetry-broken tetrahedral protein cage by modifying subunits to display a single copy of an outward-facing domain.

bioRxiv · Nov 8, 2023Biochemistry

A Suite of Designed Protein Cages Using Machine Learning Algorithms and Protein Fragment-Based Protocols

K. Meador, R. Castells-Graells, R. Aguirre, M. R. Sawaya, M. A. Arbing, T. Sherman, C. Senarathne, T. O. Yeates

The paper designs new protein cages using machine learning and fragment-based methods, reporting their structures and insights into assembly success and failure.

bioRxiv · Oct 9, 2023Biochemistry

Rigidified Scaffolds for 3-Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets

R. Castells-Graells, K. Meador, M. A. Arbing, M. R. Sawaya, M. Gee, D. Cascio, E. S. Gleave, J. E. Debreczeni, J. Breed, C. Phillips, T. O. Yeates

This paper demonstrates that rigidified scaffolds enable 3-angstrom resolution cryo-EM for small therapeutic proteins like KRAS, overcoming size limitations in structural characterization.

bioRxiv · Sep 18, 2022Biochemistry