E. J. Lee

Design of a symmetry-broken tetrahedral protein cage by a method of internal steric occlusion

The paper designs a symmetry-broken tetrahedral protein cage by modifying subunits to display a single copy of an outward-facing domain.

Interaction between PSD 95 and TRPV4 through PDZ domain controls TRPV4's localization and activity.

This paper identifies PSD95 as an interacting protein of TRPV4, showing that their interaction regulates TRPV4's localization and activity through the PDZ domain.

Realtime morphological characterization and sorting of unlabeled viable cells using deep learning

COSMOS enables real-time, unlabeled cell sorting based on morphology using deep learning, achieving high enrichment of viable cells for functional analysis.

Extracellular vesicles induce aggressive phenotype of luminal breast cancer cells by PKM2 phosphorylation

This study shows that extracellular vesicles from highly glycolytic breast cancer cells induce an aggressive phenotype in low glycolytic luminal breast cancer cells via PKM2 phosphorylation.

Targeted Eicosanoid Profiling Reveals MicroRNA-155 Shifts PGE2/PGD2 Balance Towards Oncogenic State

This study shows miR-155 shifts PGE2/PGD2 balance towards an oncogenic state by regulating enzymes involved in prostaglandin synthesis.

Out-of-register parallel β-sheets and antiparallel β-sheets coexist in 150 kDa oligomers formed by Aβ(1-42)

This paper uses solid-state NMR to show that 150 kDa Aβ(1-42) oligomers contain both parallel and antiparallel β-sheets with a unique inter-strand registry shift.