SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.
Y. Takamatsu, K. Omata, Y. Shimizu, N. Kinoshita-Iwamoto, M. Terada, T. Suzuki, S. Morioka, Y. Uemura, N. Ohmagari, K. Maeda, H. Mitsuya
This study compares the neutralizing activity of IgA and IgG antibodies against SARS-CoV-2 in COVID-19 patients and vaccine recipients, finding that IgA response is modest, peaks earlier, and declines faster than IgG.
bioRxiv · Jun 9, 2022 · PreprintMicrobiology