Author

T. Maemura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:gene regulatory network inference· 1 Research Focus:phylogenetics / evolution· 1 Approach:statistical model· 1

Frequent Co-Authors

Y. Kawaoka· 6 shared K. Iwatsuki-Horimoto· 4 shared M. Imai· 4 shared M. Ito· 4 shared P. J. Halfmann· 3 shared S. Yamayoshi· 3 shared H. Ueki· 2 shared K. Maeda· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersMicrobiology

Y. Kawaoka

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

S. Changrob, P. J. Halfmann, H. Liu, J. L. Torres, J. J. C. McGrath, G. Ozorowski, L. Li, M. Kuroda, T. Maemura, M. Huang, D. G. Wilbanks, N.-Y. Zheng, H. L. Turner, S. A. Erickson, Y. Fu, , P. C. Wilson

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

bioRxiv · Oct 31, 2022Immunology

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

R. Uraki, S. Iida, P. J. Halfmann, S. Yamayoshi, Y. Hirata, K. Iwatsuki-Horimoto, M. Kiso, M. Ito, Y. Furusawa, H. Ueki, Y. Sakai-Tagawa, M. Kuroda, T. Maemura, T. Kim, S. Mine, , Y. Kawaoka

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

bioRxiv · Aug 26, 2022 · PreprintMicrobiology

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

M. Takeshita, H. Fukuyama, K. Kamada, T. Matsumoto, C. Makino-Okamura, T. Uchikubo-Kamo, Y. Tomabechi, K. Hanada, S. Moriyama, Y. Takahashi, H. Ishigaki, M. Nakayama, C. T. Nguyen, Y. Kitagawa, Y. Itoh, , T. Takeuchi

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

bioRxiv · Jun 21, 2022 · PreprintMicrobiology

Highly-Neutralizing COVID-19-Convalescent-Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters.

Y. Takamatsu, M. Imai, K. Maeda, N. Nakajima, N. Higashi-Kuwata, K. Iwatsuki-Horimoto, M. Ito, M. Kiso, T. Maemura, Y. Takeda, K. Omata, T. Suzuki, Y. Kawaoka, H. Mitsuya

This study shows that highly-neutralizing COVID-19 convalescent plasmas significantly reduce SARS-CoV-2 viral titers and lung lesions in Syrian hamsters compared to moderately neutralizing plasmas.

bioRxiv · Jun 29, 2021Microbiology

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

A. Saito, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, , K. Sato

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

bioRxiv · Jun 17, 2021Microbiology

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck

K. M. Braun, G. K. Moreno, P. J. Halfmann, E. B. Hodcroft, D. A. Baker, E. C. Boehm, A. M. Weiler, A. K. Haj, M. Hatta, S. Chiba, T. Maemura, Y. Kawaoka, K. Koelle, D. O'Connor, T. Friedrich

This study shows SARS-CoV-2 in cats has limited within-host genetic variation and a narrow transmission bottleneck, with a variant H655Y emerging and spreading across transmission pairs.

bioRxiv · Nov 16, 2020Microbiology