Y. Shimizu

Rapid Vacuolar Sorting of the Borate Transporter BOR1 Requires the Adaptor Protein Complex AP-4 in Arabidopsis

This study shows that AP-4 is required for rapid vacuolar sorting of the borate transporter BOR1 in Arabidopsis under high-B conditions.

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

Identification of key virus--prokaryote infection pairs that contribute to viral shunt in a freshwater lake

The paper identifies key virus-prokaryote infection pairs that drive viral shunt in a freshwater lake by analyzing metagenomic data from surface and deep layers over a year.

Physicochemical properties of the vacuolar membrane and cellular factors determine formation of vacuolar invaginations

The paper shows that vacuolar invaginations in yeast result from changes in membrane physicochemical properties and cellular factors like Hfl1 and the ESCRT machinery.

SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.

This study compares the neutralizing activity of IgA and IgG antibodies against SARS-CoV-2 in COVID-19 patients and vaccine recipients, finding that IgA response is modest, peaks earlier, and declines faster than IgG.

Genetic architectures of postmating isolation and morphology of two highly diverged rockfishes (genus Sebastes)

This study investigates the genetic basis of postmating isolation and morphology in two rockfish species, identifying QTLs and genes associated with reproductive isolation and color patterns.

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

Induction of Antioxidant and Detoxifying Enzymes via the Nrf2-ARE Pathway by Oriental Bezoar

This study investigates how oriental bezoar induces antioxidant and detoxifying enzymes through the Nrf2-ARE pathway in HepG2 cells.

Protective effects of saffron and its constituent crocetin to motor symptoms, short life span and rough-eyed phenotypes in the fly models of Parkinson's disease in vivo

This study shows that saffron and crocetin protect against motor symptoms, short lifespan, and rough-eyed phenotypes in Drosophila Parkinson's disease models.

Long term sterile immunity induced by an adjuvant-containing live-attenuated AIDS virus

This study constructs a live-attenuated SHIV expressing Ag85B and shows it induces strong sterile immunity against pathogenic SHIV in macaques.