Author

K. Orlowska

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. L. Schilmiller· 1 shared R. Nault· 1 shared R. R. Fling· 1 shared T. Zacharewski· 1 shared W. J. Sink· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. L. Schilmiller

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1 paper

Recent·Most cited

Dioxin-elicited decrease in cobalamin redirects hepatic propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate accumulation

K. Orlowska, R. R. Fling, R. Nault, W. J. Sink, A. L. Schilmiller, T. Zacharewski

This study shows TCDD decreases cobalamin, inhibits MUT activity, and redirects propionyl-CoA metabolism to a Cbl-independent β-oxidation-like pathway, leading to acrylyl-CoA accumulation and hepatotoxicity.

bioRxiv · Mar 24, 2021Pharmacology & Toxicology