Author

T. Zacharewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

R. Nault· 2 shared R. R. Fling· 2 shared A. L. Schilmiller· 1 shared K. Orlowska· 1 shared S. Bhattacharya· 1 shared S. SAHA· 1 shared S. Sinha· 1 shared T. Maiti· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

R. Nault

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dose-dependent disruption of hepatic zonation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: integration of single-nuclei RNA sequencing and spatial transcriptomics.

R. Nault, S. SAHA, S. Bhattacharya, S. Sinha, T. Maiti, T. Zacharewski

This study uses single-nuclei RNA sequencing and spatial transcriptomics to show TCDD disrupts hepatic zonation in mice, leading to fat accumulation and inflammation.

bioRxiv · Jun 15, 2022Pharmacology & Toxicology

Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently shifts the gut microbiome consistent with the progression of steatosis to steatohepatitis with fibrosis

R. R. Fling, T. Zacharewski

This study shows that TCDD dose-dependently alters gut microbiota in mice, increasing Lactobacillus species and bile acid metabolism pathways, similar to human NAFLD progression.

bioRxiv · Nov 2, 2021Microbiology

Dioxin-elicited decrease in cobalamin redirects hepatic propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate accumulation

K. Orlowska, R. R. Fling, R. Nault, W. J. Sink, A. L. Schilmiller, T. Zacharewski

This study shows TCDD decreases cobalamin, inhibits MUT activity, and redirects propionyl-CoA metabolism to a Cbl-independent β-oxidation-like pathway, leading to acrylyl-CoA accumulation and hepatotoxicity.

bioRxiv · Mar 24, 2021Pharmacology & Toxicology