Author

K. P. Gopalakrishna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Tettelin· 2 shared J. L. Elder· 2 shared A. B. Chamby· 1 shared A. D'Mello· 1 shared A. H. P. Burr· 1 shared A. J. Catomeris· 1 shared A. J. Ratner· 1 shared A. N. Dammann· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

H. Tettelin

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Author profile →

3 papers

Recent·Most cited

Group B Streptococcus Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects

K. P. Gopalakrishna, G. H. Hillebrand, V. H. Bhavana, J. L. Elder, A. D'Mello, H. Tettelin, T. A. Hooven

The paper investigates how GBS Cas9 variants affect genome-wide transcription and shows nonspecific protospacer adjacent motif binding drives these effects without altering virulence.

bioRxiv · May 24, 2023 · PreprintMicrobiology

Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A

T. W. Hand, C. Johnson-Hence, K. P. Gopalakrishna, D. Bodkin, K. E. Coffey, A. H. P. Burr, S. Rahman, A. T. Rai, D. A. Abbott, Y. A. Sosa, J. T. Tometich, J. Das

This study examines the reactivity of breast milk-derived IgA against the infant microbiota, finding inter-donor heterogeneity and intra-donor stability in anti-bacterial IgA responses.

bioRxiv · Mar 16, 2023 · PreprintImmunology

MrvR, a group B Streptococcus transcription factor that controls multiple virulence traits

A. N. Dammann, A. B. Chamby, A. J. Catomeris, K. M. Davidson, H. Tettelin, J. P. van Pijkeren, K. P. Gopalakrishna, M. F. Keith, J. L. Elder, A. J. Ratner, T. Hooven

This paper identifies MrvR, a GBS transcription factor that enhances survival in amniotic fluid and virulence traits, through Tn-seq, CRISPRi, and transcriptomic analysis.

bioRxiv · Nov 17, 2020Microbiology