K. P. Wilkie

This paper discusses methods for generating virtual patient cohorts in oncology to predict treatment responses and capture inter-individual variability.

The paper constructs a mathematical model of muscle wasting in cancer cachexia, showing that blocking the myostatin/activin-ActRIIB pathway partially recovers muscle loss by activating satellite cells.

This paper develops a mathematical model of inflammation's role in tumour growth, showing that targeting both cancer and host inflammation can improve tumour control and reduce metastases.