K. Prehoda

Cooperative regulation of C1-domain membrane recruitment polarizes atypical Protein Kinase C

This study identifies the C1 domain of aPKC as a phospholipid interaction module that targets aPKC to the membrane of Drosophila neural stem cells, with other domains restricting its activity to the apical membrane during mitosis.

Negative cooperativity underlies dynamic assembly of the Par complex regulators Cdc42 and Par-3

The paper identifies negative cooperativity between Par-3 and Cdc42 in the Par complex, showing how their interaction mediates the transition from Par-3 to Cdc42 for complex polarization.

An actomyosin-polarized membrane reservoir mediates the unequal divisions of Drosophila neural stem cells

The paper shows that Drosophila neural stem cells use an actomyosin-polarized membrane reservoir to generate unequal divisions by preferentially expanding the surface area of the NSC sibling.

Energetic determinants of the Par-3 interaction with the Par complex

This study identifies the energetic contributions of Par-3's PDZ domains to its interaction with the Par complex, showing each Par-3 molecule can recruit two Par complexes during cell polarization.

Actin dependent membrane polarization reveals the mechanical nature of the neuroblast polarity cycle

The paper examines membrane dynamics during Drosophila neuroblast asymmetric division, showing actin-dependent polarization and synchronization with protein polarity.

Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

The paper identifies phases of cortical actomyosin dynamics in Drosophila neuroblasts that are coupled to the Par complex polarity cycle during cell division.