A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis
J. Shi, X. Wu, Z. Wang, F. Li, Y. Meng, R. M. Moore, J. Cui, C. Xue, K. R. Croce, A. Yurdagul, J. G. Doench, W. Li, K. S. Zarbalis, I. Tabas, A. Yamamoto, H. Zhang
This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.
bioRxiv · Jan 21, 2022Cell Biology