Author

A. Yurdagul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pathology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2

Frequent Co-Authors

I. Tabas· 2 shared O. Rom· 2 shared X. Wang· 2 shared A. C. Finney· 1 shared A. Sanyal· 1 shared A. Yamamoto· 1 shared B. Cai· 1 shared B. Finck· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPathology

I. Tabas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Loss of TIM4-Dependent Efferocytosis in Kupffer CellsPromotes Liver Fibrosis in Nonalcoholic Steatohepatitis

H. Shi, X. Wang, B. Gerlach, A. Yurdagul, M. Moore, F. Mirshahi, L. Ronzoni, A. Sanyal, L. Valenti, C.-S. Lin, I. Tabas

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

bioRxiv · Jan 30, 2024 · PreprintPathology

Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution.

T. T. Bamgbose, R. M. Schilke, O. O. Igiehon, E. H. Nkadi, D. Custis, S. Bharrhan, B. Schwarz, E. Bohrnsen, C. Bosio, R. S. Scott, A. Yurdagul, B. Finck, M. Woolard

This study shows that lipin-1 limits macrophage lipid synthesis, which supports inflammation resolution by enhancing efferocytosis.

bioRxiv · Oct 23, 2023Immunology

Cholesterol-associated Locus EHBP1 Protects against NASH Fibrosis

F. Ma, M. Longo, X. Huang, M. Meroni, S. Prakash, E. Paolini, D. Bhattacharya, S. Wang, X. Wang, S. Mughal, S. Hussain, S. Anand, A. Yurdagul, O. Rom, P. Dongiovanni, , B. Cai

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

bioRxiv · Jul 8, 2023 · PreprintPathology

Spatially Resolved Metabolites in Stable and Vulnerable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging

E. H. Seeley, Z. Liu, S. Yuan, C. Stroope, E. D. Cockerham, N. Rashdan, A. C. Finney, D. Kumar, S. Das, B. Razani, W. Liu, J. G. Traylor, O. Rom, C. B. Pattillo, A. Yurdagul

This study identifies spatially resolved metabolite differences between stable and unstable human atherosclerotic plaques using mass spectrometry imaging and RNA-seq integration.

bioRxiv · May 30, 2022 · PreprintPathology

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

J. Shi, X. Wu, Z. Wang, F. Li, Y. Meng, R. M. Moore, J. Cui, C. Xue, K. R. Croce, A. Yurdagul, J. G. Doench, W. Li, K. S. Zarbalis, I. Tabas, A. Yamamoto, H. Zhang

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

bioRxiv · Jan 21, 2022Cell Biology