A. Yamamoto

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

1 Natural Genetic Variation in a Dopamine Receptor is Associated With Variation in Female Fertility in Drosophila melanogaster

This study identifies a dopamine receptor variant linked to female fertility variation in Drosophila melanogaster using genome-wide association and functional validation.

The gut lactic acid bacteria metabolite, 10-oxo-cis-6,trans-11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling

This study identifies 10-oxo-cis-6,trans-11-octadecadienoic acid as an anti-inflammatory metabolite that suppresses colitis in mice via NRF2 pathway activation and GPCR signaling.

Scale space calibrates present and subsequent spatial learning in Barnes maze in mice

This study shows that spatial learning in mice is influenced by the scale of the Barnes maze, with larger scale spaces requiring more computational resources and prior learning in larger scales facilitating subsequent learning in smaller scales.

The tissue-specific autophagic response to nutrient deprivation

This study examines how liver and brain cells use autophagy under normal and nutrient-deprived conditions, revealing tissue-specific differences in organelle turnover and cargo capture.

Non-cell-adhesive hydrogel promotes formation of human blastoid from primed human pluripotent stem cells.

A non-cell-adhesive hydrogel enables blastoid formation from primed hPSC, mimicking blastocyst structure and differentiation.

Toxicity of House Cricket (Acheta domesticus) in Mice

This study evaluates the toxicity of House cricket powder in vitro and in vivo, finding no toxic effects at tested concentrations.

Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

The paper identifies neutralizing antibodies from early SARS-CoV-2 infections that retain activity against Omicron and other variants, highlighting the role of germinal center mutations in their broad neutralization.

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

Nuclear activation in dual-durotaxing cells on a matrix with cell-scale stiffness-heterogeneity

This study shows that mesenchymal stem cells undergoing dual-durotaxis on stiff micro-patterned gels experience amplified intracellular stress dynamics and chromatin fluctuations, which enhance cellular vigor and maintain stemness.

Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells

The paper compares SARS-CoV-2 replication in pediatric and adult nasal epithelial cells, finding lower viral titers in children for ancestral and Delta variants, but higher replication for Omicron.

Genetic diversity and distribution of indigenous soybean-nodulating bradyrhizobia in the Philippines

The paper investigates genetic diversity of bradyrhizobia in Philippine soils using PCR-RFLP and sequencing, finding B. elkanii as dominant in non-flooded soils and B. diazoefficiens/B. japonicum in flooded soils.