Author

K. R. Singleton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

K. C. Wood· 2 shared A. M. Pendergast· 1 shared A. Puissant· 1 shared A. R. Martin· 1 shared B. Mayro· 1 shared C. Cerda-Smith· 1 shared C. F. Bassil· 1 shared C. Favreau· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

K. C. Wood

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2 papers

Recent·Most cited

Drug dependence in cancer is exploitable by optimally constructed treatment holidays

J. Maltas, K. R. Singleton, K. C. Wood, K. B. Wood

This paper shows that drug-dependent cancer cells can be targeted by optimized treatment holidays, reducing population growth through adaptive therapy strategies.

Nature Ecology & Evolution · Nov 27, 2023Peer-reviewedCancer Biology

MCB-613 exploits a collateral sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

C. F. Bassil, G. R. Anderson, B. Mayro, K. N. Askin, P. S. Winter, S. Gruber, T. M. Hall, J. P. Hoj, C. Cerda-Smith, H. M. Hutchinson, S. T. Killarney, K. R. Singleton, L. Qin, K. Jubien-Girard, C. Favreau, , K. C. Wood

The paper identifies MCB-613 as a compound that targets KEAP1 in EGFR inhibitor-resistant NSCLC cells, exploiting its selective essentiality through covalent inhibition.

bioRxiv · Jan 17, 2023 · PreprintCancer Biology