K. B. Wood

Heterogeneous collateral effects in daptomycin-resistant E. faecalis

This study examines collateral effects of daptomycin resistance in E. faecalis, revealing diverse phenotypic outcomes and trade-offs in drug resistance and growth.

Drug dependence in cancer is exploitable by optimally constructed treatment holidays

This paper shows that drug-dependent cancer cells can be targeted by optimized treatment holidays, reducing population growth through adaptive therapy strategies.

Modeling spatial evolution of multi-drug resistance under drug environmental gradients

The paper models the spatial evolution of multi-drug resistance in bacteria under varying drug gradients using a reaction-diffusion system and Price equation framework.

Scale-free correlations and criticality in an experimental model of brain cancer

The paper studies collective motion of glioblastoma cells and finds scale-free correlations suggesting the system is near a critical point.

Dynamic collateral sensitivity profiles highlight challenges and opportunities for optimizing antibiotic sequences

The paper studies how collateral sensitivity to antibiotics changes over time in E. faecalis, finding that resistance dominates early while sensitivity increases later, with population-specific trends.

Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance

The paper uses a Price equation framework to analyze how drug interactions and collateral effects influence the evolution of multidrug resistance in bacteria.

Evolution in alternating environments with tunable inter-landscape correlations

This study examines how alternating between correlated fitness landscapes affects evolutionary fitness in asexual populations, finding that correlation and landscape ruggedness influence steady-state fitness outcomes.

Spatial segregation and cooperation in radially expanding microbial colonies under antibiotic stress

This study shows that antibiotic resistance in microbial colonies can be cooperative, with sensitive cells surviving in the presence of resistant cells under antibiotic stress.

Fluorescent reporter plasmids for single-cell and bulk-level composition assays in E. faecalis

The paper develops and evaluates fluorescent reporter plasmids for monitoring E. faecalis population dynamics at single-cell and bulk levels, identifying optimal reporters and pairs for composition assays.

Delayed antibiotic exposure induces population collapse in enterococcal communities with drug-resistant subpopulations

The paper shows that delayed antibiotic exposure can cause population collapse in E. faecalis communities with drug-resistant subpopulations, revealing density-dependent dynamics.

Using selection by non-antibiotic stressors to sensitize bacteria to antibiotics

This study shows that non-antibiotic stressors can sensitize bacteria to antibiotics through sequential adaptation, revealing potential strategies to combat antibiotic resistance.

Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance

The paper quantifies collateral sensitivity in Enterococcus faecalis and develops a model to design optimal drug policies that reduce antibiotic resistance.

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

This study shows that maintaining large populations of drug-sensitive bacteria can delay the rise of drug-resistant bacteria using containment strategies.

Antibiotic interactions shape short-term evolution of resistance in E. faecalis

This study quantifies how antibiotic combinations affect resistance evolution in E. faecalis, showing varied growth and resistance adaptation depending on drug interactions and concentrations.

Tuning Spatial Profiles of Selection Pressure to Modulate the Evolution of Resistance

This study uses a stochastic model to show how spatial profiles of selection pressure affect the evolution of drug resistance, finding that optimal spatial tuning can slow resistance fixation.