Multiple Mechanisms Underlie State-Independent Inhibitory Effects of Norfluoxetine on TREK-2 K2P Channels
P. Proks, M. Schewe, L. J. Conrad, S. Rao, K. Rathje, K. E. Rodstrom, E. P. Carpenter, T. Baukrowitz, S. J. Tucker
This study identifies multiple mechanisms by which norfluoxetine inhibits TREK-2 K2P channels, showing state-independent effects and interactions with filter stability and voltage-dependent gating.
bioRxiv · Oct 29, 2020Biophysics