Author

P. Proks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:electrophysiology· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

S. J. Tucker· 4 shared M. Schewe· 3 shared T. Baukrowitz· 3 shared E. P. Carpenter· 2 shared K. E. Rodstrom· 2 shared L. J. Conrad· 2 shared S. Newstead· 2 shared A. Baronina· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersBiophysics

S. J. Tucker

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Author profile →

5 papers

Recent·Most cited

CryoEM Structure of the human THIK-1 K2P K+ Channel Reveals a Lower 'Y-gate' Regulated by Lipids and Anaesthetics

K. E. Rodstrom, B. Eymsh, P. Proks, M. S. Hayre, C. Madry, A. Rowland, S. Newstead, T. Baukrowitz, M. Schewe, S. J. Tucker

The paper presents a cryoEM structure of the human THIK-1 K2P K+ channel, revealing structural features and regulatory mechanisms involving lipids and anaesthetics.

bioRxiv · Jun 26, 2024 · PreprintBiophysics

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

K. E. J. Rodstrom, A. Cloake, J. Sormann, A. Baronina, K. H. M. Smith, A. C. W. Pike, J. Ang, P. Proks, M. Schewe, I. Holland-Kaye, S. R. Bushell, J. Elliott, E. Pardon, T. Baukrowitz, R. J. Owens, , S. J. Tucker

The paper identifies nanobodies that selectively modulate TREK-2 channel activity and reveals their binding mechanisms through structural analysis.

bioRxiv · Oct 19, 2023Biophysics

Effects of Ionic Strength on Gating and Permeation of TREK-2 K2P channels

L. J. Conrad, P. Proks, S. J. Tucker

This study investigates how ionic strength affects TREK-2 channel gating and permeation, finding that high internal K+ inhibits the channel through increased ionic strength, while BL1249 increases conductance but not open probability.

bioRxiv · Jul 8, 2021Biophysics

Multiple Mechanisms Underlie State-Independent Inhibitory Effects of Norfluoxetine on TREK-2 K2P Channels

P. Proks, M. Schewe, L. J. Conrad, S. Rao, K. Rathje, K. E. Rodstrom, E. P. Carpenter, T. Baukrowitz, S. J. Tucker

This study identifies multiple mechanisms by which norfluoxetine inhibits TREK-2 K2P channels, showing state-independent effects and interactions with filter stability and voltage-dependent gating.

bioRxiv · Oct 29, 2020Biophysics

Evaluating Inositol phospholipid interactions with Inward Rectifier Potassium Channels and characterising their role in Disease

T. Pipatpolkai, R. A. Corey, P. Proks, F. M. Ashcroft, P. J. Stansfeld

This study uses molecular dynamics to evaluate phosphoinositide interactions with hKir channels and shows how mutations affect PIP2 binding affinity.

bioRxiv · Sep 3, 2020Biochemistry