Author

K. Schuschel

Primary ORCID profile (0000-0002-5417-8950 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

K. SchuscheliD1 paper · Goethe University Frankfurt

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

H. Issa· 2 shared A. Sinz· 1 shared C. Beyer· 1 shared C. Ihling· 1 shared D. Heckl· 1 shared D. Reinhardt· 1 shared E. Regenyi· 1 shared H. Blair· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

H. Issa

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2 papers

Recent·Most cited

Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8;21)-positive Acute Myeloid Leukaemia

H. Issa, L. Swart, M. Rasouli, M. Ashtiani, S. Nakjang, n. jyotsana, K. Schuschel, M. Heuser, H. Blair, O. Heidenreich

This study uses siRNA-loaded lipid nanoparticles to target the RUNX1/ETO fusion gene in t(8;21)-AML, showing improved survival and long-term inhibition of leukaemic growth.

bioRxiv · Sep 21, 2022Cancer Biology

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

O. Alejo-Valle, K. Weigert, R. Bhayadia, M. Ng, S. Emmrich, C. Beyer, K. Schuschel, C. Ihling, A. Sinz, M. Flasinski, H. Issa, E. Regenyi, M. Labuhn, D. Reinhardt, M.-L. Yaspo, , J.-H. Klusmann

This paper identifies ARID3A repression by miR-125b as a key driver of megakaryoblastic leukemia, showing that restoring ARID3A expression can reverse differentiation arrest in AMKL.

bioRxiv · Apr 26, 2021Cancer Biology