Author

S. Emmrich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

V. N. Gladyshev· 5 shared A. Seluanov· 4 shared V. Gorbunova· 4 shared A. Trapp· 3 shared Z. Zhang· 3 shared F. Tolibzoda Zakusilo· 2 shared J. Ablaeva· 2 shared J.-H. Klusmann· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersImmunology

V. N. Gladyshev

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

Z. Zhang, X. Tian, J. Y. Lu, K. Boit, J. Ablaeva, F. T. Zakusilo, S. Emmrich, D. Firsanov, E. Rydkina, S. A. Biashad, Q. Lu, A. Tyshkovskiy, V. N. Gladyshev, S. Horvath, A. Seluanov, V. Gorbunova

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

bioRxiv · May 4, 2023 · PreprintPhysiology

Naked mole-rat hematopoietic stem and progenitors are highly quiescent with an inherent myeloid bias

S. Emmrich, A. Trapp, F. Tolibzoda Zakusilo, M. Mariotti, M. E. Straight, Z. Zhang, S. Gray, M. G. Drage, Z. Ke, M. Takasugi, J.-H. Klusmann, V. N. Gladyshev, A. Seluanov, V. Gorbunova

This study identifies unique hematopoietic features in naked mole-rats, including myeloid bias and quiescent stem cells, linked to their exceptional longevity.

bioRxiv · Aug 1, 2021Cell Biology

Ectopic cervical thymi and no thymic involution until midlife in naked mole-rats

S. Emmrich, F. Tolibzoda Zakusilo, A. Trapp, X. Zhou, Q. Zhang, E. M. Irving, M. G. Drage, Z. Zhang, V. N. Gladyshev, A. Seluanov, V. Gorbunova

This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.

bioRxiv · Aug 1, 2021Immunology

Epigenetic predictors of maximum lifespan and other life history traits in mammals

C. Z. Li, A. Haghani, T. R. Robeck, D. Villar, A. T. Lu, J. Zhang, C. G. Faulkes, H. Vu, J. Ablaeva, D. M. Adams, R. Ardehali, A. Arneson, C. S. Baker, K. Belov, D. T. Blumstein, , A. J. Jasinska

The paper develops methylation-based models to predict maximum lifespan and other life history traits in mammals using data from 12,000 samples across 192 species.

bioRxiv · May 16, 2021 · PreprintEvolutionary Biology

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

O. Alejo-Valle, K. Weigert, R. Bhayadia, M. Ng, S. Emmrich, C. Beyer, K. Schuschel, C. Ihling, A. Sinz, M. Flasinski, H. Issa, E. Regenyi, M. Labuhn, D. Reinhardt, M.-L. Yaspo, , J.-H. Klusmann

This paper identifies ARID3A repression by miR-125b as a key driver of megakaryoblastic leukemia, showing that restoring ARID3A expression can reverse differentiation arrest in AMKL.

bioRxiv · Apr 26, 2021Cancer Biology

The hematopoietic landscape at single-cell resolution reveals unexpected stem cell features in naked mole-rats

S. Emmrich, M. Mariotti, M. Takasugi, M. E. Straight, A. Trapp, V. N. Gladyshev, A. Seluanov, V. Gorbunova

This study profiles the hematopoietic system of naked mole-rats at single-cell resolution, revealing unique stem cell features associated with longevity and cancer resistance.

bioRxiv · Nov 29, 2019 · PreprintImmunology