Cytotoxic lymphocytes use mechanosurveillance to target biophysical vulnerabilities in cancer
M. Tello-Lafoz, K. Srpan, J. Hu, Y. Romin, A. Calo, K. C. Hsu, J. Massague, M. Huse, E. E. Er
This study shows that cancer cells with increased MRTF signaling are more rigid and vulnerable to immune cells, revealing a mechanical aspect of immunosurveillance.
bioRxiv · Apr 21, 2020 · PreprintImmunology