Y. Romin

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

PSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state.

The paper shows that PSMA-bearing extracellular vesicles from prostate cancer cells promote a pro-angiogenic tumor microenvironment by increasing VEGF-A, angiogenin, and 4EBP-1 phosphorylation.

Cytotoxic lymphocytes use mechanosurveillance to target biophysical vulnerabilities in cancer

This study shows that cancer cells with increased MRTF signaling are more rigid and vulnerable to immune cells, revealing a mechanical aspect of immunosurveillance.

Potential hydrodynamic cytoplasmic transfer between mammalian cells: Cell-projection pumping

The paper identifies a novel hydrodynamic mechanism, cell-projection pumping, for cytoplasmic transfer between mammalian cells, supported by mathematical modeling and simulations.