Stromal cell-contact dependent PI3K and APRIL induced NF-κB signaling complement each other to prevent mitochondrial- and endoplasmic reticulum stress induced cell death of bone marrow plasma cells
R. Cornelis, S. Hahne, A. Taddeo, G. Petkau, D. Malko, P. Durek, M. Thiem, L. Heiberger, E. Mohr, C. Klaeden, K. Tokoyoda, F. Siracusa, B. F. Hoyer, F. Hiepe, M.-F. Mashreghi, , A. Radbruch
The paper shows that stromal cell contact and APRIL signaling via PI3K and NF-κB pathways prevent mitochondrial and ER stress-induced apoptosis in bone marrow plasma cells.
bioRxiv · Nov 21, 2019Immunology