Author

F. Melchers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Petkau· 2 shared M.-F. Mashreghi· 2 shared P. Durek· 2 shared A. Radbruch· 1 shared A. Taddeo· 1 shared B. F. Hoyer· 1 shared C. Klaeden· 1 shared D. Malko· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

G. Petkau

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2 papers

Recent·Most cited

MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes.

P. K. Jani, G. Petkau, Y. Kawano, U. Klemm, G. M. Guerra, G. A. Heinz, F. Heinrich, P. Durek, M.-F. Mashreghi, F. Melchers

This study shows that miR-221/222 in HSC and MPP maintains quiescence and multipotency by suppressing IEGs and myelo/granulopoiesis genes, with implications for improving bone marrow transplants.

bioRxiv · Jan 30, 2023 · PreprintImmunology

Stromal cell-contact dependent PI3K and APRIL induced NF-κB signaling complement each other to prevent mitochondrial- and endoplasmic reticulum stress induced cell death of bone marrow plasma cells

R. Cornelis, S. Hahne, A. Taddeo, G. Petkau, D. Malko, P. Durek, M. Thiem, L. Heiberger, E. Mohr, C. Klaeden, K. Tokoyoda, F. Siracusa, B. F. Hoyer, F. Hiepe, M.-F. Mashreghi, , A. Radbruch

The paper shows that stromal cell contact and APRIL signaling via PI3K and NF-κB pathways prevent mitochondrial and ER stress-induced apoptosis in bone marrow plasma cells.

bioRxiv · Nov 21, 2019Immunology