M.-F. Mashreghi

Single cell analysis reveals CD45RClow/-TNFR2+CD29lowCD8+ Tregs with superior activity

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

Human ADA2 deficiency is characterized by the absence of an intracellular hypoglycosylated form of adenosine deaminase 2

The paper identifies an intracellular hypoglycosylated form of ADA2 absent in DADA2 patients, linking its absence to reduced deaminase activity and variant pathogenicity.

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

This study shows IL-33 reduces IL-22 production in innate lymphoid cells, increasing resistance to Streptococcus pneumoniae infection, and links genetic variation in IL-33 signaling to human pneumonia.

MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes.

This study shows that miR-221/222 in HSC and MPP maintains quiescence and multipotency by suppressing IEGs and myelo/granulopoiesis genes, with implications for improving bone marrow transplants.

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

This study identifies functional heterogeneity in human regulatory T-cells within inflamed arthritic joints using single-cell sequencing and flow cytometry.

Induction of cross-reactive antibody responses against the RBD domain of the spike protein of SARS-CoV-2 by commensal microbiota

This study identifies commensal bacteria that induce cross-reactive anti-RBD IgA antibodies against SARS-CoV-2 in humans and mice.

Antigen-driven PD1+Tox+Eomes+ and PD1+Tox+BHLHE40+ synovial T lymphocytes regulate chronic inflammation in situ

The paper identifies distinct subpopulations of synovial T lymphocytes in JIA patients using single-cell RNA-sequencing and shows their roles in regulating chronic inflammation.

Stromal cell-contact dependent PI3K and APRIL induced NF-κB signaling complement each other to prevent mitochondrial- and endoplasmic reticulum stress induced cell death of bone marrow plasma cells

The paper shows that stromal cell contact and APRIL signaling via PI3K and NF-κB pathways prevent mitochondrial and ER stress-induced apoptosis in bone marrow plasma cells.

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

The paper identifies discrete populations of isotype-switched memory B cells in murine spleen and bone marrow, with distinct locations and characteristics.