Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts
P. Gonzalez-Davila, M. Schwalbe, A. Danewalia, R. Wardenaar, B. Dalile, K. Verbeke, S. K. Mahata, S. El Aidy
This study shows that gut microbiota transplantation from CST-KO mice to wild-type mice induces colonic fibrosis and tight junction impairment, suggesting a causal role for microbiota in intestinal dyshomeostasis linked to catestatin deficiency.
bioRxiv · Feb 24, 2022Microbiology