S. K. Mahata

Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts

This study shows that gut microbiota transplantation from CST-KO mice to wild-type mice induces colonic fibrosis and tight junction impairment, suggesting a causal role for microbiota in intestinal dyshomeostasis linked to catestatin deficiency.

Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis

This study shows that Wnt5A signaling reduces susceptibility to visceral leishmaniasis by limiting infection progression and preserving immune cell function in mice.

Chromogranin A plays a crucial role in the age-related development of insulin resistance and hypertension

This study shows that Chromogranin A deficiency in mice prevents age-related insulin resistance and hypertension, with hypertension reversing spontaneously as mice age.

Catestatin selects for the colonization of antimicrobial-resistant gut bacterial communities

This study shows that catestatin (CST) alters gut microbiota composition and promotes antimicrobial resistance in CST-KO mice, with implications for inflammatory bowel disease.

Catestatin regulates the colonic mucus layer in inflammatory bowel disease

This study shows that catestatin (CST) regulates the colonic mucus layer in IBD, with CST levels elevated in IBD patients and CST-KO mice showing increased mucus thickness.

The anti-inflammatory peptide Catestatin blocks chemotaxis

This study shows that the anti-inflammatory peptide Catestatin blocks chemotaxis of monocytes and granulocytes to inflammatory chemokines like CCL2 and MIP-2.

Catestatin induces glycogenesis by stimulating phosphoinositide 3-kinase-AKT pathway

This study shows that Catestatin increases hepatic glycogen synthesis in insulin-resistant mice by enhancing insulin signaling through the phosphoinositide 3-kinase-AKT pathway.

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.