Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
J. Felix, K. Weinhaupl, C. Chipot, F. Dehez, A. Hessel, D. F. Gauto, C. Morlot, O. Abian, I. Gutsche, A. Velazquez-Campoy, P. Schanda, H. Fraga
The paper investigates how bortezomib activates ClpP protease by mimicking a substrate and inducing allosteric conformational changes that enhance its interaction with ClpX.
bioRxiv · Mar 15, 2019Biochemistry