A. Velazquez-Campoy

Allosteric feedback inhibition of deoxy-D-xylulose-5-phosphate synthase involves monomerization of the active dimer.

The paper investigates how IPP and DMAPP feedback regulate DXS enzyme activity by inducing monomerization, which affects enzyme stability and pathway flux.

Tyrosinase from mushroom Agaricus bisporus as an inhibitor of the Hepatitis C virus

This study demonstrates that tyrosinases from Agaricus bisporus inhibit Hepatitis C virus replication with high antiviral activity, potentially offering a new low-cost treatment.

UMP inhibition and sequential firing in aspartate transcarbamoylase open ways to regulate plant growth

The paper shows that modulating aspartate transcarbamoylase (ATC) in Arabidopsis affects plant growth, revealing a unique feedback inhibition mechanism and sequential firing of active sites.

Mitochondrial cytochrome c liberates the nucleophosmin-sequestered ARF tumor suppressor in the nucleolus

This study identifies mitochondrial cytochrome c as a factor that releases ARF tumor suppressor from NPM sequestration in the nucleolus upon DNA damage.

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors

The paper investigates how bortezomib activates ClpP protease by mimicking a substrate and inducing allosteric conformational changes that enhance its interaction with ClpX.

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.