A. Hessel

Predominant myosin super-relaxed state in canine myocardium with naturally occurring dilated cardiomyopathy

This study finds that myosin in DCM-affected dogs has increased super-relaxed state and is rescued by EMD-57033.

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection

This paper shows that Pseudomonas aeruginosa's Exotoxin A activates the NLRP1 inflammasome via EEF2 inactivation, causing epithelial damage and pyroptosis, and identifies ZAK as a key sensor in this process.

Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR

The paper uses MAS NMR and computational methods to show a flexible loop in TET2 aminopeptidase is critical for catalytic function and substrate processing.

Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection

This study shows that Pseudomonas aeruginosa induces Caspase-1-dependent pyroptosis in neutrophils, leading to incomplete NETosis and promoting bacterial spread.

Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

This study identifies phospholipid peroxidation as a mechanism enhancing ExoU phospholipase activity, leading to cell necrosis and supporting Pseudomonas aeruginosa pathogenesis.

Structural basis of client specificity in mitochondrial membrane-protein chaperones

The paper determines how two mitochondrial chaperones bind different membrane proteins by analyzing their structural interactions and identifies factors that influence client specificity.

Architecture and assembly dynamics of the essential mitochondrial TIM chaperone systems

The paper derives a structural model of the TIM9{middle dot}10{middle dot}12 complex using NMR, X-ray scattering, and MD simulations, revealing dynamic subunit exchange and conformational changes.

Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products

This study identifies Irgm2 and Gate-16 as cooperative regulators that dampen non-canonical inflammasome activation by reducing caspase-11 targeting to intracellular bacteria.

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors

The paper investigates how bortezomib activates ClpP protease by mimicking a substrate and inducing allosteric conformational changes that enhance its interaction with ClpX.

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

This study investigates how crystal packing affects microsecond dynamics of ubiquitin using solid-state NMR and MD simulations, revealing altered thermodynamics and kinetics of conformational exchange.