Author

F. Dehez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

C. Chipot· 3 shared A. Hessel· 1 shared A. J. Pedersen· 1 shared A. Le Roy· 1 shared A. Monari· 1 shared A. S. Kristensen· 1 shared A. Trkola· 1 shared A. Velazquez-Campoy· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

C. Chipot

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT3 receptors

U. Lopez-Sanchez, L. J. Munro, L. K. Ladefoged, A. J. Pedersen, C. C. Brun, S. M. Lyngby, D. Baud, M. G. Pedersen, S. C. R. Lummis, B. Bang-Andersen, B. Schiott, C. Chipot, G. Schoehn, J. Neyton, F. Dehez, , A. S. Kristensen

This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.

bioRxiv · Feb 23, 2024 · PreprintBiochemistry

Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction

A.-S. Banneville, C. Bouthier de la Tour, C. Hognon, J.-P. Colletier, J.-M. Teulon, A. Le Roy, J.-L. Pellequer, A. Monari, F. Dehez, F. Confalonieri, P. Servant, J. Timmins

This study characterizes DdrC, a DNA damage-induced protein in D. radiodurans, showing it compacts DNA and modulates its topology to aid in DNA repair.

bioRxiv · Oct 27, 2021Microbiology

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

C. Caillat, D. Guilligay, J. Torralba, N. Friedrich, J. L. Nieva, A. Trkola, C. Chipot, F. Dehez, W. Weissenhorn

This paper presents the crystal structure of HIV-1 gp41 in a fusion intermediate state, revealing conformational plasticity and how antibodies block membrane fusion.

bioRxiv · Nov 12, 2020Microbiology

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors

J. Felix, K. Weinhaupl, C. Chipot, F. Dehez, A. Hessel, D. F. Gauto, C. Morlot, O. Abian, I. Gutsche, A. Velazquez-Campoy, P. Schanda, H. Fraga

The paper investigates how bortezomib activates ClpP protease by mimicking a substrate and inducing allosteric conformational changes that enhance its interaction with ClpX.

bioRxiv · Mar 15, 2019Biochemistry