K. Wynne

Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma

The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.

Loss of Polycomb Repressive Complex 2 function causes asparaginase resistance in T-acute lymphoblastic leukemia through decreased WNT pathway activity

The paper identifies that PRC2 loss in T-ALL reduces WNT pathway activity, leading to asparaginase resistance, which can be overcome by proteasome inhibition.

Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells

This study shows that KSR1 is essential for maintaining the transformed phenotype of BRAFV600E mutant melanoma cells by promoting cell survival and inhibiting senescence and apoptosis.

Interplay between Polycomb PCGF protein interactomes revealed by screening under endogenous conditions

The paper identifies novel interactions of PCGF1, PCGF2, and PCGF4 using AP-MS under endogenous conditions, revealing functional pathways and mutual regulation among these proteins.

Rapid ageing and species identification of natural mosquitoes for malaria surveillance

This paper develops a deep learning method to rapidly identify mosquito species and age from mid-infrared spectra, with high accuracy for malaria vectors.

Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids

This paper uses vibrational spectroscopy to analyze G-quadruplexes and B-DNA, revealing unique low-frequency vibrational modes not predicted by current theoretical models.

Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo

Human bone marrow mesenchymal stem/stromal cell behaviour is coordinated via mechanically activated osteocyte-derived extracellular vesicles

This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance human MSC recruitment and osteogenesis, suggesting their potential as a cell-free therapy for bone regeneration.