Author

G. van Mierlo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

B. Deplancke· 3 shared M. Vermeulen· 3 shared J. Russeil· 2 shared P. Rainer· 2 shared P. W. Jansen· 2 shared V. Gardeux· 2 shared W. Saelens· 2 shared A. B. van Spriel· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

B. Deplancke

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Dissecting reprogramming heterogeneity at single-cell resolution using scTF-seq

W. Liu, W. Saelens, P. Rainer, M. Biocanin, V. Gardeux, A. Gralak, G. van Mierlo, J. Russeil, T. Liu, W. Chen, B. Deplancke

The paper introduces scTF-seq, a method to study TF dose-dependent reprogramming in mouse MSCs, revealing heterogeneity in cell fate and TF sensitivity.

bioRxiv · Jan 30, 2024Cell Biology

Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma

D. Gannon, E. Lagan, A. J. Silva, P. Bibawi, A. Doherty, D. Nimmo, R. McCole, C. Monger, G. Genesi, A. Vanderlinden Dibekeme, J. Innes, L. Yang, B. Chen, G. van Mierlo, P. W. Jansen, , G. Brien

The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.

bioRxiv · Dec 2, 2023Cancer Biology

A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion

R. Ferrero, P. Rainer, J. Russeil, M. Zachara, J. Pezoldt, G. van Mierlo, V. Gardeux, W. Saelens, D. Alpern, L. Favre, S. Mantziari, T. Zingg, N. Pitteloud, M. Suter, M. Matter, , B. Deplancke

The paper identifies an omental-specific stromal population that inhibits adipogenesis via IGFBP2 secretion in human adipose tissue.

bioRxiv · May 1, 2023Cell Biology

Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy

L. Weiss, J. Weiden, Y. Dölen, E. Grad, E. A. W. van Dinther, M. Schluck, L. J. Eggermont, G. van Mierlo, U. Gileadi, A. Bartolo-Ibars, R. Raave, M. A. J. Gorris, K. Verrijp, M. Valente, B. Deplancke, , R. Hammink

This paper introduces immunofilaments that expand T cells in vivo, showing efficacy against melanoma when combined with immune checkpoint blockade.

bioRxiv · Oct 14, 2022Immunology

Growth inhibition of Akkermansia muciniphila by a secreted pathobiont sialidase

G. H. van Muijlwijk, E. Bröring, G. van Mierlo, P. W. Jansen, M. Vermeulen, P. C. Aerts, J. P. van Putten, N. W. Palm, M. R. de Zoete

The paper identifies a secreted sialidase from Allobaculum that inhibits Akkermansia muciniphila growth by altering its glycometabolic niche.

bioRxiv · Mar 15, 2022 · PreprintMicrobiology

Single-embryo phosphoproteomics reveals the importance of intrinsic disorder in cell cycle dynamics

J. M. Valverde, G. Dubra, H. van den Toorn, G. van Mierlo, M. Vermeulen, A. J. R. Heck, P. Knipscheer, L. Krasinska, D. Fisher, M. Altelaar

The paper uses single-embryo phosphoproteomics to show that phosphorylation of intrinsically disordered proteins by cell cycle kinases drives switch-like mitotic reorganization.

bioRxiv · Aug 29, 2021 · PreprintCell Biology

Unravelling the effect of a potentiating anti-Factor H antibody on atypical hemolytic uremic syndrome associated factor H variants

G. Dekkers, M. Brouwer, J. Jeremiasse, A. Kamp, R. M. Biggs, G. van Mierlo, S. Lauder, S. Katti, T. W. Kuijpers, T. Rispens, I. Jongerius

This study investigates how a potentiating anti-FH antibody enhances the function of wild-type and aHUS-associated FH variants.

bioRxiv · Apr 8, 2020 · PreprintImmunology