Author

K. Z. Guiley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

A. N. Iness· 1 shared J. Felthousen· 1 shared K. Shokat· 1 shared L. Litovchick· 1 shared M. Dozmorov· 1 shared Q. Zheng· 1 shared S. M. Rubin· 1 shared V. Ananthapadmanabhan· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. N. Iness

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2 papers

Recent·Most cited

Strain-release alkylation of Asp12 enables mutant selective GTP-state targeting of K-Ras(G12D)

Q. Zheng, Z. Zhang, K. Z. Guiley, K. Shokat

This paper develops covalent inhibitors that target the K-Ras(G12D) mutation by crosslinking aspartate-12 in both GDP- and GTP-states, effectively suppressing cancer cell proliferation and tumor growth.

bioRxiv · Jul 1, 2023 · PreprintCancer Biology

The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb

A. N. Iness, J. Felthousen, V. Ananthapadmanabhan, K. Z. Guiley, M. Dozmorov, S. M. Rubin, L. Litovchick

This study shows that B-Myb disrupts the DREAM complex by affecting LIN52 protein levels and DYRK1A kinase activity, contributing to cancer progression.

Oncogene · Sep 11, 2018Peer-reviewedCancer Biology