Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter:Sodium Symporter LeuT
P. S. Merkle, K. Gotfryd, M. A. Cuendet, K. Z. Leth-Espensen, U. Gether, C. J. Loland, K. D. Rand
This paper uses HDX-MS to study LeuT's structural dynamics during substrate translocation, revealing that partial unwinding of transmembrane helices facilitates the transition between outward- and inward-facing states.
bioRxiv · Jun 28, 2017Biophysics