U. Gether

Membrane curvature association of amphipathic helix 8 drives constitutive GPCR endocytosis

The paper identifies amphipathic helix 8 as a driver of constitutive GPCR endocytosis through membrane curvature association.

Role of Dopamine Neurons in Familiarity

This study shows that multiple familiarization sessions reduce dopamine neuron activity in mice, enhancing novelty discrimination, while single sessions do not, and chemogenetic inhibition during single sessions improves novelty recognition.

Structural basis of organic cation transporter-3 inhibition

The paper determines the cryo-EM structure of OCT3 and analyzes genetic variants to understand its function and inhibition.

Relative enrichment - a density-based colocalization measure for single-molecule localization microscopy

The paper introduces a density-based colocalization measure for SMLM data, demonstrating its application on simulated and neuronal data.

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis

The paper identifies coding variants in PICK1 that impair its BAR domain function, leading to altered insulin granule biogenesis in diabetic patients.

Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter:Sodium Symporter LeuT

This paper uses HDX-MS to study LeuT's structural dynamics during substrate translocation, revealing that partial unwinding of transmembrane helices facilitates the transition between outward- and inward-facing states.