Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT
S. G. Schmidt, A. Nygaard, J. A. Mindell, C. J. Loland
This study investigates how K+ binding affects substrate transport and conformational changes in LeuT, showing that K+ affinity and selectivity are influenced by mutations in the Na1 site.
bioRxiv · Apr 4, 2023Biophysics