Interactions between Viperin, IRAK1 and TRAF6 couple innate immune signaling to antiviral ribonucleotide synthesis
A. B. Dumbrepatil, S. Ghosh, A. M. Patel, P. A. Malec, K. Zegalia, J. D. Hoff, R. T. Kennedy, E. N. G. Marsh
This study shows that Viperin, IRAK1, and TRAF6 interact to link innate immune signaling with antiviral ddhCTP synthesis through ubiquitination and enzymatic activation.
bioRxiv · Jan 11, 2019 · PreprintBiochemistry