Author

E. N. G. Marsh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. B. Dumbrepatil· 5 shared R. T. Kennedy· 4 shared A. M. Patel· 3 shared S. Ghosh· 3 shared K. Sajja· 2 shared T. J. Grunkemeyer· 2 shared A. I. Nesvizhskii· 1 shared A. S. Fleischhacker· 1 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersBiochemistry

A. B. Dumbrepatil

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Author profile →

6 papers

Recent·Most cited

Viperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway

T. J. Grunkemeyer, S. Ghosh, A. M. Patel, K. Sajja, J. Windak, V. Basrur, Y. S. Kim, A. I. Nesvizhskii, R. T. Kennedy, E. N. G. Marsh

This study shows viperin reduces cholesterol levels by inhibiting key enzymes in the biosynthetic pathway, though the exact mechanism remains unclear.

bioRxiv · Feb 19, 2021 · PreprintBiochemistry

Absence of heme at the catalytic site of heme oxygenase-2 triggers its lysosomal degradation

L. Liu, A. B. Dumbrepatil, A. S. Fleischhacker, E. N. G. Marsh, S. W. Ragsdale

This study identifies that heme absence at the catalytic site of HO2 triggers its lysosomal degradation, distinct from other HRM-containing proteins and HO1.

bioRxiv · Jun 21, 2020 · PreprintBiochemistry

Viperin binds STING and enhances the type-I interferon response following dsDNA detection

K. M. Crosse, E. A. Monson, A. B. Dumbrepatil, M. Smith, Y.-Y. Tseng, K. H. Van der Hoek, P. A. Revill, D. C. Tscharke, E. N. G. Marsh, M. R. Beard, K. J. Helbig

This study identifies Viperin's role in enhancing the type-I interferon response by binding STING and promoting TBK1 ubiquitination, thereby strengthening antiviral immunity against dsDNA.

bioRxiv · Dec 17, 2019Immunology

The Interaction of Viperin with Hepatitis C Virus Non-Structural Protein 5A Inhibits the Catalytic Activity of Viperin

S. Ghosh, A. M. Patel, T. J. Grunkemeyer, A. B. Dumbrepatil, K. Zagalia, R. T. Kennedy, E. N. G. Marsh

This study shows viperin interacts with NS5A and VAP-33, reducing NS5A levels and viperin activity, suggesting NS5A evolved to inhibit ddhCTP synthesis.

bioRxiv · Oct 30, 2019 · PreprintBiochemistry

Targeting Viperin to the Mitochondrion Inhibits the Thiolase Activity of the Trifunctional Enzyme Complex

A. B. Dumbrepatil, K. A. Zegalia, K. Sajja, R. T. Kennedy, E. N. G. Marsh

This paper investigates how HCMV co-opts viperin to inhibit mitochondrial thiolase activity and alter ATP levels, revealing a novel mechanism of viral immune evasion.

bioRxiv · Oct 30, 2019Biochemistry

Interactions between Viperin, IRAK1 and TRAF6 couple innate immune signaling to antiviral ribonucleotide synthesis

A. B. Dumbrepatil, S. Ghosh, A. M. Patel, P. A. Malec, K. Zegalia, J. D. Hoff, R. T. Kennedy, E. N. G. Marsh

This study shows that Viperin, IRAK1, and TRAF6 interact to link innate immune signaling with antiviral ddhCTP synthesis through ubiquitination and enzymatic activation.

bioRxiv · Jan 11, 2019 · PreprintBiochemistry