Author

A. M. Patel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

E. N. G. Marsh· 3 shared R. T. Kennedy· 3 shared S. Ghosh· 3 shared A. B. Dumbrepatil· 2 shared T. J. Grunkemeyer· 2 shared A. I. Nesvizhskii· 1 shared B. G. Wiggins· 1 shared E. Pizzi· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

E. N. G. Marsh

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Author profile →

6 papers

Recent·Most cited

The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer

J. K. Eaton, P. Chatterji, L. Furst, S. Basak, A. M. Patel, Y. Y. Sweat, L. L. Cai, K. Dave, R. A. Victoria, E. Pizzi, J. Noorbakhsh, G. Tian, J. A. S. Roth, J. Hynes, G. Xing, , V. S. Viswanathan

This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.

bioRxiv · Apr 28, 2024 · PreprintCancer Biology

The Antiviral Enzyme, Viperin, Activates Protein Ubiquitination by the E3 Ubiquitin Ligase, TRAF6

A. M. Patel, N. Marsh

This study shows viperin activates TRAF6 to enhance ubiquitination, promoting immune signaling and protein degradation.

bioRxiv · Feb 21, 2021Biochemistry

Viperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway

T. J. Grunkemeyer, S. Ghosh, A. M. Patel, K. Sajja, J. Windak, V. Basrur, Y. S. Kim, A. I. Nesvizhskii, R. T. Kennedy, E. N. G. Marsh

This study shows viperin reduces cholesterol levels by inhibiting key enzymes in the biosynthetic pathway, though the exact mechanism remains unclear.

bioRxiv · Feb 19, 2021 · PreprintBiochemistry

The human liver microenvironment shapes the homing and function of CD4+ T-cell populations

B. G. Wiggins, L. J. Pallett, X. Li, S. P. Davies, O. E. Amin, U. S. Gill, A. M. Patel, K. Aliazis, Y. S. Liu, G. M. Reynolds, G. Hirschfield, P. F. Kennedy, Y. Huang, M. M. Maini, Z. Stamataki

This study identifies two distinct CD4+ T cell subsets in the human liver, characterized by CD69 expression levels, with different functional profiles and microenvironmental requirements.

bioRxiv · Aug 3, 2020Immunology

The Interaction of Viperin with Hepatitis C Virus Non-Structural Protein 5A Inhibits the Catalytic Activity of Viperin

S. Ghosh, A. M. Patel, T. J. Grunkemeyer, A. B. Dumbrepatil, K. Zagalia, R. T. Kennedy, E. N. G. Marsh

This study shows viperin interacts with NS5A and VAP-33, reducing NS5A levels and viperin activity, suggesting NS5A evolved to inhibit ddhCTP synthesis.

bioRxiv · Oct 30, 2019 · PreprintBiochemistry

Interactions between Viperin, IRAK1 and TRAF6 couple innate immune signaling to antiviral ribonucleotide synthesis

A. B. Dumbrepatil, S. Ghosh, A. M. Patel, P. A. Malec, K. Zegalia, J. D. Hoff, R. T. Kennedy, E. N. G. Marsh

This study shows that Viperin, IRAK1, and TRAF6 interact to link innate immune signaling with antiviral ddhCTP synthesis through ubiquitination and enzymatic activation.

bioRxiv · Jan 11, 2019 · PreprintBiochemistry