R. T. Kennedy

Conserved 5-methyluridine tRNA modification modulates ribosome translocation

This study identifies m5U54 as a conserved tRNA modification that modulates ribosome translocation and tRNA maturation.

Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation

This study identifies and quantifies new mRNA modifications in S. cerevisiae and shows how they affect translation elongation.

Mapping enzyme catalysis with metabolomic biosensing

The paper introduces a method to sense enzyme product formation using host cell metabolism and mass spectrometry to map enzyme activity and mutagenesis effects.

Viperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway

This study shows viperin reduces cholesterol levels by inhibiting key enzymes in the biosynthetic pathway, though the exact mechanism remains unclear.

The Interaction of Viperin with Hepatitis C Virus Non-Structural Protein 5A Inhibits the Catalytic Activity of Viperin

This study shows viperin interacts with NS5A and VAP-33, reducing NS5A levels and viperin activity, suggesting NS5A evolved to inhibit ddhCTP synthesis.

Targeting Viperin to the Mitochondrion Inhibits the Thiolase Activity of the Trifunctional Enzyme Complex

This paper investigates how HCMV co-opts viperin to inhibit mitochondrial thiolase activity and alter ATP levels, revealing a novel mechanism of viral immune evasion.

Interactions between Viperin, IRAK1 and TRAF6 couple innate immune signaling to antiviral ribonucleotide synthesis

This study shows that Viperin, IRAK1, and TRAF6 interact to link innate immune signaling with antiviral ddhCTP synthesis through ubiquitination and enzymatic activation.