Systematic Determination of the Impact of Structural Edits on Peptide Accumulation into Mycobacteria
Rachita Dash, Zichen Liu, Irene Lepori, Mahendra D. Chordia, Karl L. Ocius, Kadie A. Holsinger, Han Zhang, Ryan Kenyon, Wonpil Im, M. Sloan Siegrist, Marcos M. Pires
The paper evaluates how structural modifications like macrocyclization and N-alkylation affect peptide accumulation in Mycobacterium tuberculosis using a novel assay, showing macrocyclization generally enhances accumulation while N-alkylation has context-dependent effects.
ACS Chemical Biology · Aug 1, 2025Peer-reviewedMicrobiology