Mahendra D. Chordia

Identification and Evaluation of Benzimidazole- Agonists of Innate Immune Receptor NOD2

The paper identifies benzimidazole compounds, including nocodazole, as NOD2 agonists with potential therapeutic benefits over existing MDP-based agonists.

Split-luciferin Assay for Real-time Measurement of Cytosolic Molecular Accumulation in Live Mycobacteria

This paper introduces D-CLAP, a split-luciferin assay to measure real-time cytosolic accumulation of compounds in live mycobacteria, showing that modifying carboxylates increases accumulation and antimycobacterial activity.

Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach

The paper identifies Hsp90 inhibitors as MHC-I inducers and develops novel compounds using click chemistry to enhance T cell activation and reduce toxicity.

Systematic Determination of the Impact of Structural Edits on Peptide Accumulation into Mycobacteria

The paper evaluates how structural modifications like macrocyclization and N-alkylation affect peptide accumulation in Mycobacterium tuberculosis using a novel assay, showing macrocyclization generally enhances accumulation while N-alkylation has context-dependent effects.

The mycomembrane differentially and heterogeneously restricts antibiotic permeation

This paper shows that the mycomembrane of Mycobacterium tuberculosis and M. smegmatis differentially and heterogeneously restricts antibiotic permeation using the PAC-MAN method.

Profiling Cytosolic Drug Delivery in Mammalian Cells: A Generalizable Assay for Intracellular Accumulation

The paper introduces the CHAMP assay to measure cytosolic drug accumulation in mammalian cells, showing how molecular structure affects penetration.