Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease
Hamin Lee, Esmeralda Villavicencio Gonzalez, Elias M. Rivera, Mark A. Durham, Ronald Richman, E.H.Y. Chu, Kailey Xia, Hu Chen, Zhandong Liu, Surabi Veeraragavan, Binoy Shivanna, Huda Yahya Zoghbi
The paper shows that different isoforms of CIC interact with paralogs ATXN1 and ATXN1L, leading to distinct phenotypes and explaining tissue-specific vulnerability in neurological diseases.
Genes & Development · Jul 20, 2026Peer-reviewedMolecular Biology